Configuring Drupal
Configuring Drupal is straight forward. There's an option in Site Configuration to turn on clean URLs, as well as set the date and time, if different from the server. There's also a Site Information page that reflects the information entered when the site was first installed, and includes fields to change the site title, mission statement, logo, and so on.
Another configuration page is Input Formats, where you can set whether you want to use filtered HTML or full HTML by default, as well as establish exactly what is handled by Drupal. I modified the full HTML option to not do element correction or automatically create links from URLs. I run my site as XHTML (which I'll get into more, later), and I prefer to do my own markup.
There are other configuration options but many of these reflect installed and activated modules.